Compared to NPFs, PCa‐derived CAFs have a higher proliferative rate and a higher expression of different genes which are recognized as markers of CAF phenotype such as αSMA, estrogen receptor‐α (ESR1) and secreted frizzled‐related protein 1 (SFRP1) (Clark et al., 2013; Ellem et al., 2014; Joesting et al., 2005; Ting et al., 2015). This evidence concerns the gene ESR1 and posterior cortical atrophy.