This up‐regulation of TAGLN in CAFs is in agreement with studies demonstrating up‐regulation of this protein in the majority of PCa‐derived CAFs (Webber et al., 2016) and in gastric carcinoma‐derived CAFs where it regulates CAF‐mediated metastasis of cancer cells through the regulation of MMP2 expression (Yu et al., 2013). Here, MMP2 is linked to posterior cortical atrophy.