When comparing the sensitivity of tissue markers using immunostaining [29], the positive staining of p63 was about 99% in both lung squamous cell carcinoma and adenocarcinoma, followed by high-molecular-weight cytokeratin (HMCK) (97%), cytokeratin 5/6 (93%), SRY-related HMG-box 2 (80%), thrombomodulin (79%), desmocollin-3 (72.7%), S100A7 (71%), S100A2 (63.3%), and GPC3 (47%), while desmocollin-3 in lung squamous cell carcinoma alone was 100%, followed by cytokeratin 5/6 (98%), SRY-related HMG-box 2 (96%), GPC3 (92%), S100A7 (87%), thrombomodulin (80%), S100A2 (65%), p63 (52%), and HMCK (33%). The gene discussed is DSC3; the disease is squamous cell lung carcinoma.