MicroRNA-133b is a small non-coding RNA which targets Sirt1s, suppressing its expression in hepatocellular carcinoma cells, increasing the proliferation and invasion of hepatocellular carcinoma cells through the activation of E-cadherin expression, and repressing expression of GPC3 and the anti-apoptotic proteins (Bcl-2, Bcl-xL, and Mcl-1) [26]. This evidence concerns the gene BCL2 and hepatocellular carcinoma.