This paper also lists two other double variants: OBSCN E963K + DSP R1537C and OBSCN R4856H + SCN5A S216L; both the DSP and the SCN5A variant have been previously noted as being associated with cardiomyopathies but not causative (Marangoni et al. 2011; Xu et al. 2010). This evidence concerns the gene SCN5A and cardiomyopathy.