In recent years, advances in DNA sequencing technology have allowed the study of the giant proteins of the sarcomere, notably truncating mutations in the titin gene (TTNtv), which have been found to be responsible for up to 25% of familial DCM cases (Roberts et al. 2015), and mutations in nebulin (NEB), the most common mutations causing skeletal muscle myopathies such as nemaline myopathy (Lehtokari et al. 2014). This evidence concerns the gene NEB and familial dilated cardiomyopathy.