TTN and familial dilated cardiomyopathy: Taking into consideration the findings from large multicohort studies delineating TTNtv pathogenicity in DCM and identification of an internal TTN promoter named Cronos which could rescue the N-terminal TTN truncation (Zou et al. 2015), Deo (2016) proposed a quantitative classification model for clinical use in order to classify and predict the pathogenicity of TTNtv in clinical and population cohorts.