The expression of LRG1 is significantly down-regulated in the left ventricle of hypertensive S.LWEx12x2x3x5 rat exhibiting concentric cardiac hypertrophy with augmented contractile function (GDS3873 _ 1374626_at _ Lrg1) (Gopalakrishnan et al. 2011). This evidence concerns the gene LRG1 and cardiac hypertrophy.