Compared to controls, patients with MD showed higher levels of CRP (t110.5=4.01, P<0.001), lower levels of circulating IL-10 (t30.8=−2.09; P=0.045), as well as a higher IL-6/IL-10 ratios (t84.1=2.71, P=0.008). This evidence concerns the gene IL10 and Menkes disease.