TP53 and acute myeloid leukemia: HDAC8 has also been shown to regulate transcription through targeting non-histone proteins, such as adenoviral E1A-12 protein [64], the inversion-16 fusion gene products in acute myeloid leukemia cells [65], p53 [66], protein phosphatase (PP) 1 [67], heat shock proteins [68], α-actin [69], human ever-shorter telomeres 1B [70], estrogen-related receptor-α [71] and possibly multiple other proteins [72,73].