Kumari et al. (2007) showed that the PS 5-Aminolevulinic acid (5-ALA) induces apoptosis in human glioblastoma U87MG cells by downregulation of BIRC3 and activation of calpain, caspase-9, and caspase-3 [32]. The gene discussed is CASP9; the disease is glioblastoma.