CHKA and cancer: Increased tCho and PCho in cancer has been attributed to a higher choline uptake [81,82], as well as increased expression and activity of the enzymes choline kinase alpha (CK-α) [82,83], the isoform which is primarily upregulated in cancers [84] together with phospholipases C [82,85] and D [82,86] and glycerophosphocholine phosphodiesterases [87,88] (Figure 4).