p16 overexpression may therefore be considered a surrogate marker of persistent HPV infection and measurement of its expression allows triage of a higher risk group of hrHPV‐positive women to colposcopy.19 In addition, co‐reading of p16 and hematoxylin and eosin (H&E) stained biopsies has been shown to improve observer agreement in the diagnosis of CIN.20, 21 The reported sensitivity of p16 immunohistochemistry (IHC), however, varies due to difficulties in reproducible reading of the slides, lack of standardized reporting, and uncertainty about the best cut‐off point. Here, CDKN2A is linked to cervical squamous intraepithelial neoplasia.