KRAS and cancer: Remarkably: (i) expression of KrasG12C isoform 2A conferred enhanced MPE competence to PANO2 cells compared with KrasG12C isoform 2B, although the later was more abundantly expressed by KRAS-mutant cancer cells; and (ii) mutant KRAS expression converted even benign HEK293T cells to MPE competence (Fig. 2a,b; Table 2; Supplementary Fig. 5).