In addition, markers of cell cycle progression (Ccna2, Ccnb1, Ccnb2), cell proliferation (Mki67, Pcna) and HCC (α-fetoprotein or Afp)24, were profoundly induced by FGF19 expression in livers from Stat3f/f mice, but not Stat3ΔHep mice (Supplementary Fig. 1e and f). This evidence concerns the gene CCNA2 and hepatocellular carcinoma.