To further determine the functional significance of IL-6 in FGF19-induced HCC progression, we injected AAV-FGF19 intravenously into wild type (Il6+/+) or Il6-deficient (Il6−/−) mice, and evaluated HCC development 12 months post AAV administration (Supplementary Fig. 6a). Here, IL6 is linked to hepatocellular carcinoma.