Colonic tumours are increased with regard to incidence and size in mice with IEC‐specific knockout of SOCS3 in an inflammation‐induced (azoxymethane/dextran sodium sulphate [DSS]) cancer model; while over‐expression of SOCS3 in vitro has been shown to result in decreased cell proliferation and wound repair 2, 6. The gene discussed is SOCS3; the disease is cancer.