Nonetheless, we did not find an association between IL‐18R/IL‐18 expression and insulin resistance in T2D patients which may be due, in part, to confounding effects of diabetes‐related immunometabolic complications or comorbidities that are often found in these subjects; and which also explains as to why HOMA‐IR is a better indicator of insulin resistance in non‐diabetic rather than diabetic subjects. This evidence concerns the gene IL18 and Insulin resistance.