As expected, in T2D patients as well, IL‐18R adipose tissue mRNA expression was significantly upregulated in obese as compared with lean/overweight individuals (Obese: 7.0 ± 0.8 Lean/Overweight: 2.4 ± 0.5; P < 0.05) (Fig. 3A). Here, IL18R1 is linked to type 2 diabetes mellitus.