Besides, the present findings highlight correlation of the altered adipose tissue expression of IL‐18R/IL‐18 with tissue inflammation and insulin resistance in obesity while the systemic changes in relation to inflammatory biomarkers such as TNF‐α, IL‐1β, IFN‐γ, IL‐18, CCL‐2, CCL‐5, and C‐reactive protein still remain unclear. Here, IL18R1 is linked to obesity due to melanocortin 4 receptor deficiency.