Adipose tissue infiltrating monocytes/macrophages can play a role in the adipose tissue inflammation in morbid obesity and, in this regard, our data show that the increased adipose tissue IL‐18R/IL‐18 gene expression in obesity/T2D was associated positively with monocyte/macrophage markers such as CD11c, CD86, CD68, and CD163. Here, IL18 is linked to obesity due to melanocortin 4 receptor deficiency.