Moreover, according to some previous studies, we found that many alkaloids were identified to have PPARs agonistic activity: picrasidine C and picrasidine N (Zhao et al., 2016a; Zhao et al., 2016b), isolated from the root of Picrasma quassioides, were identified to have PPARα and PPARβ agonistic activity respectively (Zhao et al., 2016a; Zhao et al., 2016b); evodiamine, an indole alkaloid extracted from the Chinese medicine evodia, has been shown to inhibit tumor cell invasion and protect the cardiovascular system through activating PPARγ (Ge et al., 2015). Here, PPARA is linked to neoplasm.