CD4 and neoplasm: ,12 Investigations into the drivers of immune responses to melanoma elucidated not only a set of tumor-specific melanoma-antigen-encoding gene families (MAGE, BAGE, GAGE), but also several antigenic epitopes derived from human melanocyte lineage-specific proteins (MART-l/Melan-A, gpl00, gp75 and tyrosinase) recognized by CD8+ and CD4+ T cells.13-15