Depending on the soluble signals released in the tumor microenvironment, B cells can be polarized to undergo class switching and express potentially weak immune-activating antibody isotypes such as IgG480 or IgG2 and IgA,45 as part of chronic inflammation and immune-escape processes associated with human melanoma79 (Figs. 1 and 2). The gene discussed is CD79A; the disease is neoplasm.