Multivariate analysis indicated that tumor size (>2) (HR = 5.511, 95% CI: 1.223–46.08, P = 0.032) and plakoglobin (HR = 5.052, 95% CI: 1.449–16.41, P = 0.013) were independent prognostic factors for DMFS, and that E-cadherin (HR = 8.045, 95% CI: 2.014–53.84, P = 0.002) was an independent prognostic factor for OS (Additional file 3: Table S2). Here, CDH1 is linked to neoplasm.