The present observations of decreased expression of p75NTR in both the cerebral cortex of AD model mice and SH-SY5Y cells treated with Aβ are consistent with the findings of many human and animal studies (Kordower et al., 1989; Arendt et al., 1997; Salehi et al., 2000). The gene discussed is NGFR; the disease is Alzheimer disease.