Likewise, levels of the p75NTR-ectodomain—the ectodomain shedding of p75NTR that protects neurons against Aβ toxicity—have been shown to be reduced in the brains of AD patients and an AD mouse model (APP/PS1 double-transgenic mice; Yao et al., 2015). The gene discussed is NGFR; the disease is Alzheimer disease.