PPARGC1A and Parkinson disease: PARIS/ZNF746 was found to be more abundant in the striatum and SN patients with autosomal recessive and sporadic PD, as well as in PARK2 knock-out mice (Shin et al., 2011) Moreover, viral vector-mediated overexpression of PARIS/ZNF746 in the mouse SN led to DA neurodegeneration, which was prevented by concomitant Parkin or PGC-1α overexpression.