Moreover, Parkin-deficiency was associated with excessive cytokine production, such as TNFα, interleukin (IL)-6 or monocyte chemoattractant protein-1 (MCP-1) production, following LPS treatment either in vitro or in vivo (Tran et al., 2011; de Leseleuc et al., 2013). The gene discussed is CCL2; the disease is hyperinsulinemic hypoglycemia, familial, 4.