PINK1 and neoplasm: Notably, a recent study suggested that the metabolic syndrome caused in mice by deletion of the T2DM susceptibility gene TP53INP1 (tumor protein 53-induced nuclear protein 1), involved in tumor suppression and regulation of autophagy, is due to impaired PINK1/PARKIN-mediated mitophagy, associated with oxidative stress and chronic inflammation (Seillier et al., 2015).