CaM abundance is decreased in depression disorders (Kang et al., 2012), and mutations in the CaM binding site of Kv7.2 are associated with distinct epilepsy phenotypes (Borgatti et al., 2004; Weckhuysen et al., 2012; Soldovieri et al., 2014). The gene discussed is KCNQ2; the disease is epilepsy.