MAPT and Alzheimer disease: AD is a progressive neurodegenerative disorder characterized by the formation and accumulation of amyloid plaques and tau protein tangles in the brain (Querfurth and LaFerla, 2010) Previous studies with resting state fMRI have revealed that the DMN is particularly vulnerable in AD (Buckner et al., 2005; Lee E. S. et al., 2016).