Earlier studies have found that C-Kit mutation is associated with unfavorable prognosis of adult AML with t (8; 21) ( Boissel et al., 2006[2]), and AML children with t (8;21) or CBF-rearrangement (Shimada et al., 2006[28]; Manara et al., 2014[17]), yet other investigations indicated that no significant relevance existed between C-Kit mutation and the prognosis of AML children and adults (Pollard et al., 2010[23]; Goemans et al., 2005[9]; Shih et al., 2008[27]; Riera et al., 2013[26]). Here, KIT is linked to acute myeloid leukemia.