Through network analysis, miR-196b was identified as one of the candidate miRNA biomarkers involved in the leukemogenesis of childhood AML, due to a significantly larger NOD (number of degree) and TFP (transcription factor percentage) (Wilcoxon test, p<0.05, NOD=30, TFP=0.191) (Zhang et al., 2014[35]; Yan et al., 2015[34]). The gene discussed is TRIM39; the disease is acute myeloid leukemia.