The long-established hypoxia-induced gene [11–13] PLOD2 is histologically over-expressed in sarcoma, glioblastoma, breast cancer and hepatocellular carcinoma [14–17], and it is an independent prognostic factor in glioblastoma and hepatocellular carcinoma [15, 17]. Here, SESN2 is linked to hepatocellular carcinoma.