Key regulators of Hedgehog pathway, particularly SHH, SMO and GLI1 are aberrantly stimulated in various cancers including lung cancer8, 12–14 and have crosstalk with other neoplastic related cascade like RAS/RAF/MEK/ERK, PI3K/AKT/mTOR, EGFR, and Notch9, 35. Here, SMO is linked to cancer.