SHH and non-small cell lung carcinoma: For validation of SBE-induced in vivo repression of SHH pathway in NSCLC, Ki67 and SHH as proliferative and Hedgehog pathway marker respectively were analyzed in immunohistochemistry (IHC) staining of those xenografts and animal lungs with metastasis burdens (Fig. 4E and F, Fig. S3).