We have previously identified BCL-XL upregulation as a main effector in preventing RAS mutant CRC cell lines from anti-EGFR antibody induced apoptosis, and in CD20-positive B-cell Non-Hodgkin Lymphoma (B-NHL) cells from rituximab-induced apoptosis [33, 57]. The gene discussed is EGFR; the disease is B-cell non-Hodgkin lymphoma.