2013), ES‐HF canines showed significantly lower EF, higher PAP as well as PCWP, and tended to have lower CO and higher LA weights compared to normals. Urine flow and urinary sodium and potassium excretion were significantly lower, and GFR trended to be reduced. Plasma BNP, ANP, cGMP, ANG II, aldosterone, and renin were all elevated compared to normal (Table 1). The gene discussed is REN; the disease is hydrops fetalis.