SERPINE1 and keratoconus: Several inflammatory and renal injury genes in KC were up‐regulated over 50‐fold, similar to LA (e.g., 139.0‐fold for SELE and 55.9‐fold for ICAM1 in KC and 293.7‐fold for IL6, 143.8‐fold for CCL2 and 133.6‐fold for CSF3, and 86.7‐fold for SERPINE1 in LA), while apoptosis and fibrosis genes were generally up‐regulated less than 50‐fold.