The importance of prophylactic low-dose low- molecular-weight heparin use in diseases such as CD in necessary cases lies in the following: anti-TG2 antibodies bind to human endometrial endothelial cells and impair endometrial angiogenesis by inhibiting the activation of matrix metalloprotease-2 (MMP-2) activity (1, 8). This evidence concerns the gene MMP2 and Cowden disease.