Accordingly, inhibition of these kinases greatly sensitized MLL-ENL-, MLL-, AF9-, NUP98-HoxA9-, and HoxA9/Meis1-expressing AML cells to killing by the clinical SM birinapant, in a TNFR1-dependent manner (Lalaoui et al., 2016). This evidence concerns the gene KMT2A and acute myeloid leukemia.