Having demonstrated staining for uPAR in DCIS (Fig. 6b, top row) and associated stromal cells (Fig. 6b, bottom row), we compared the effects of both rPAI-1 and the uPAR blocking antibody ATN-617 [47] on degradation of DQ-collagen IV in MAME DCIS cultures. The gene discussed is PLAUR; the disease is ductal breast carcinoma in situ.