The p.R211C mutation of the TGFB2 propeptide may dysregulate active TGFB2 in a similar way with the TGFB1 mutations and may be a possible factor for the systemic bone metastasis, requiring further investigation when more samples from thymic adenocarcinoma are available. Here, TGFB2 is linked to thymus gland adenocarcinoma.