In dengue, for example, the use of N-sulfonylanthranilic acid derivatives has been described in allosteric inhibition of the NS5 protein [17], while beta-d-2’-ethynyl-7-deaza-adenosine triphosphate (2’E-7D-ATP) has been used in competition with the natural nucleotide [18]. This evidence concerns the gene RAF1 and dengue disease.