TNF and Arthritis: The last follow-up MRI revealed no signs of inflammation in 12 patients (6 with no signs of arthritis and 6 with minimal residuals in a form of minor patchy enhancement of cervical synovia, which could be considered as normal), in 2 patients improvement of arthritis, but with MRI signs of persistent active inflammation (remnants of synovial thickening with moderate contrast enhancement in patients # 5 and # 6, both received anti-TNFα for 6 months)(Fig. 1), and in one significant improvement of arthritis, but with mild to moderate MRI signs of active inflammation (patient#8) (Fig. 2).