TGFB1 and colorectal carcinoma: This pathway was enriched 6.34-fold, with 9 genes neighboring the CRC risk alleles listed in this pathway: BMP4, CDKN1A, BMP2, LAMA5, CDH1, LAMC1, TCF7L2, TGFB1, and CTNNB1. Gene Ontology analysis identified an enrichment for multiple biological processes (FDR ≤ 0.05), such as cell junction organization, tissue morphogenesis, regulation of SMAD protein phosphorylation, and odontogenesis (Table 2).