This SNP is located in the intronic region of the overlapping genes COLCA2 and COLCA1. The two genes are transcribed from opposite strands, and C11orf53 is >55 Kb upstream of rs3802842, neighboring COLCA1. This risk allele is associated with lower expression of all three regulated genes in both normal and tumor tissue. The gene discussed is COLCA1; the disease is neoplasm.