NFE2L2 and acute myeloid leukemia: When tested for the effect of pharmacological inhibition of Nrf2 on chemosensitivity of AML cell lines, primary AML cells as well as normal BMMNCs, we observed that co-administration of brusatol in resistant AML cell lines expressing high levels of NRF2 (THP1 and U937) followed by ATO, Ara-C and Dnr improved their sensitivity to these drugs (Fig 5A–5D and S9A–S9C Fig).