According to the meta-analysis and the cancer genome atlas (TCGA) data, we found that heparanase expression was up-regulated in most breast cancer specimens, and elevated heparanase expression was associated with increased lymph node metastasis, larger tumor size, higher histological grade, and poor survival, and suggested that targeting heparanase might improve treatments for breast cancer patients [17]. The gene discussed is HPSE; the disease is breast cancer.