Interestingly, expression of mesoderm-specific transcript (Mest)/paternally expressed gene 1 (Peg1), an inhibitory factor of Wnt signaling [38], was inversely associated with OPN dose in tumors, and it was significantly elevated in tumors compared with adjacent non-tumor parts in Min/OPN(−/−) mice (Figure 4m). The gene discussed is SPP1; the disease is neoplasm.