Expression levels of EMT-related genes, Snail and Twist, were higher in colorectal tumors than those in adjacent colorectal mucosa in Min/OPN(+/+) mice, and those were decreased in Min/OPN(+/−) mice, but not in Min/OPN(−/−) mice (Figure 4n,o). This evidence concerns the gene SPP1 and colorectal neoplasm.