Osteopontin (OPN), also known as secreted phosphoprotein 1 (SPP1), binds to several integrin receptors including CD44v6, a splicing variant of CD44, which is a marker of colon cancer stem cells, and regulates cell motility, invasion, chemotaxis, and cell survival [1,2]. This evidence concerns the gene SPP1 and malignant colon neoplasm.