Figure 2 shows the size distribution of colorectal tumors in mice. Compared to Min mice, the number of tumors showed a tendency to decrease at all sizes in mice with OPN deficiency. The number of tumors ranging between 3.0 mm and 5.0 mm in diameter was statistically lower in Min/OPN(+/−) (0.4 ± 0.6, p < 0.01) and Min/OPN(−/−) (0.4 ± 0.6, p < 0.05) mice than that in Min/OPN(+/+) mice (1.0 ± 1.1). Here, SPP1 is linked to colorectal neoplasm.