Both colon tumor incidences and multiplicities in Min/OPN(+/−) and Min/OPN(−/−) mice were significantly lower than those in Min/OPN(+/+) mice, being 27/56 (48%) (p < 0.01) and 0.6 ± 0.8 (p < 0.01), 18/36 (50%) (p < 0.05) and 0.8 ± 0.9 (p < 0.01) vs. 20/25 (80%) and 1.6 ± 1.7, respectively. Here, SPP1 is linked to colonic neoplasm.