This demonstrates that MYC is capable of upregulating HDAC2 gene expression, that MYC-induced HDAC2 overexpression contributes to MYC-induced cancer cell proliferation, and that HDAC2 is likely to be one of the key factors responsible for MYC-induced malignant transformation, tumor initiation and progression in vivo [112]. The gene discussed is HDAC2; the disease is neoplasm.