GABRE and breast cancer: miR-452 is expressed as an intronic transcript from the GABRE gene locus.70 Pearson’s correlation analysis of two independent breast cancer data sets, the METABRIC and Enerly data sets,71, 72 respectively, showed that miR-452 expression correlated strongly with that of its parent transcript, GABRE (R2 values of 0.484 and 0.786 in the METABRIC and Enerly data sets, respectively; Figure 6b), indicating GABRE can be used as a surrogate for miR-452 expression in data sets, such as KM Plotter, that lack microRNA data.