VEGFA is expressed in a variety of tumors and its overexpression is associated with poor prognosis and death from metastasis.5, 6, 7 VEGFA functions are not restricted to vasculogenesis and angiogenesis.8 Autocrine VEGFA cooperates with EGFR to drive tumor development9 and VEGFA has also been shown to drive tumor metastasis.4, 10, 11 Indeed, patients with metastatic breast cancer have higher circulating VEGFA levels than those without metastasis.12 This evidence concerns the gene EGFR and neoplasm.