Notably, miR-452 expression correlates inversely with glioblastoma survival and inhibits glioma stem cells and tumorigenesis by targeting CSC mediators, Bmi1, LEF1 and TCF4.95 Thus, miR-452 may not only regulate Sox2-driven EMT via Slug, but may also serve a dual role at the interface between EMT and CSC regulation. This evidence concerns the gene BMI1 and central nervous system cancer.