Although high intratumor VEGFA levels detected by immunohistochemistry have been linked to poor breast cancer outcome, most studies have been small and results controversial.96, 97 Our analysis showed breast cancers in the highest quartile of VEGFA expression fare worse than all others, and the prognostic value of high VEGFA levels is increased by sequential addition of high SOX2, SNAI2 and decreased GABRE (a surrogate for miR-452) expression. This evidence concerns the gene SNAI2 and breast carcinoma.