High VEGFA alone conferred a 1.69-fold higher risk of death (DSS HR (95% CI) =1.69 (1.25–2.3), P=0.000595: Figure 6e, left), and METABRIC cancers in the top quartile of both VEGFA and SOX2 had even worse outcome (DSS HR (95% CI) =1.76 (1.3–2.38), P=0.000199; Figure 6e, right). This evidence concerns the gene VEGFA and cancer.