These findings are consistent with BET family members having discrete roles in pancreatic β-cells, with BRD2 reported to have a role in insulin secretion,35 and to induce insulin resistance by enhancing signalling mediated by the mechanistic target of rapamycin (mTOR) and phosphoinositide 3-kinase (PI3K).36 Interestingly, our RNA-Seq data indicated potential changes in mTOR and PI3K signalling (Supplementary Table S2), thereby suggesting possible roles of BRD2 and mTOR signalling in PNETs and BNETs. The gene discussed is INS; the disease is Insulin resistance.