DNER and Insulin resistance: These findings are consistent with BET family members having discrete roles in pancreatic β-cells, with BRD2 reported to have a role in insulin secretion,35 and to induce insulin resistance by enhancing signalling mediated by the mechanistic target of rapamycin (mTOR) and phosphoinositide 3-kinase (PI3K).36 Interestingly, our RNA-Seq data indicated potential changes in mTOR and PI3K signalling (Supplementary Table S2), thereby suggesting possible roles of BRD2 and mTOR signalling in PNETs and BNETs.