In NETs such mechanisms may involve dysregulation of histone expression, as reported in other cancers, which have altered abundance of H2B protein isoforms that may disrupt their critical roles in DNA packaging and lead to chromosomal abnormalities during cell division that prevents cell cycle progression and leads to cell death.41 Moreover, our results in NET cells have shown that JQ1 causes a significant increase in expression of HIST2H2BE, HIST2HBD and HIST2H2BG (Figure 4), thereby indicating that the BRD proteins may regulate H2B expression. The gene discussed is H2BC21; the disease is cancer.