Among them, we further focused on L1CAM. L1CAM is a type-I transmembrane protein, and L1CAM expression in cancer cells promotes cancer cell proliferation, invasion and metastasis.24, 25, 26, 27 Higher expression of L1CAM correlates with poor prognosis of patients with breast, pancreas and squamous cancer,28, 29, 30 and L1CAM expression is induced by HIF-1.31, 32 However, the role of L1CAM in fibroblasts on cancer progression has not been evaluated yet. This evidence concerns the gene HIF1A and cancer.