SOX30 and colorectal carcinoma: It is known that the functional significance of a miR is commonly specific to tissue and cell type, and regulation of its targets is similarly highly dependent on cell type and context.12 In addition, miRs function as a fine-tuning mechanism in controlling gene expression.10, 11 While a miR potentially targets multiple mRNAs, a mRNA may in turn be regulated by a group of miRs.34 It is conceivable that, in addition to SOX30 mRNA, miR-645 targets mRNAs that similarly play roles in CRC cell proliferation and survival.