HMGB1 and epilepsy: Cellular localization of HMGB1 was assessed immunohistochemically in the hippocampus of rats exposed to electrically induced SE, a well-characterized model of epilepsy (20, 21), and these hippocampi were compared with sham controls (see Supplemental Methods; supplemental material available online with this article; https://doi.org/10.1172/JCI92001DS1).