To further test whether localized light activation of CatCh-expressing CD8+ Tc induces systemic effects and thus controls non-illuminated tumour growth at a distal secondary site, we adoptively transferred Pmel-1 CD8+ Tc expressing CatCh into C57BL/6 mice bearing two subcutaneous B16 tumours at the ear and flank, followed by vaccination with hgp10025–33 peptide. The gene discussed is CD8A; the disease is neoplasm.