CD8A and neoplasm: Similarly, aTreg-mediated suppression of CD8+ Tc anti-tumour cytotoxicity was significantly decreased by the TGFβ superfamily type I activin receptor-like kinase receptor inhibitor SB431542 (Fig. 1k), suggesting that the Treg-mediated suppression of tumour killing through intracellular Ca2+ signals is, at least in part, TGFβ-dependent.