F2R and periodontal disorder: Most recently, it was shown by Spolidorio et al. [54] that parstatin, a 41-amino acid peptide released upon PAR1 activation, has potential anti-inflammatory effects since it decreases inflammatory cell infiltration, myeloperoxidase (MPO) activity, and proinflammatory mediators' levels, including IL-1β, IL-6, and TNF-α in gingival tissues of rats subjected to experimental periodontal disease.