We have shown recently that SIRT2, the most abundant of sirtuins in the adipose tissue, also regulates hypoinflammatory response of late sepsis in obese mice with sepsis via direct deacetylation of NFĸB p65 [18] consistent with literature implicating the role of SIRT2 in neuroinflammation and collagen-induced arthritis among other inflammatory conditions [19, 20]. This evidence concerns the gene SIRT2 and Sepsis.