In summary, to our knowledge, this is the first report exploring the potential relevance on molecular mechanism between NLPR1, NLRP3, and P2X7R polymorphisms and partial seizures in a Chinese Han population, and our data suggest that there was a significant correlation between NLRP1 (rs878329, G>C) polymorphism and partial seizures in the study population. The gene discussed is NLRP1; the disease is Focal-onset seizure.