The difference between the function of NLRP1 and NLRP3 polymorphism on the epilepsy susceptibility may result from that their cell-specific expression and divergent biological functions; that is, NLRP1 mainly exists in neurons and is essential for the pyroptotic cell death in epilepsy pathogenesis, whereas the NLRP3 is mainly expressed in microglia and is responsive to immune activation. The gene discussed is NLRP3; the disease is epilepsy.