PMP22 and peripheral neuropathy: Interestingly, Trembler-J (Tr-J) mice harbour a punctual missense mutation in peripheral myelin protein 22 (pmp-22) gene, constituting a model of hypomyelinating human peripheral neuropathy Charcot-Marie-Tooth-1E (CMT1-E, Li et al., 2013; formerly classified as CMT1-A; Valentijn et al., 1992).