The first description of clinical myocardial involvement of CHIKV infection was reported in 1972, when Obeyeskereet al presented a cohort of 10 patients who had a history of arbovirus-like syndrome, serological evidence of Dengue IgM antibodies or CHIKV haemagglutination inhibition (HI) antibodies test, and complement-fixation antibodies tst in high titres, and now had clinical and electrocardiographic evidence of myocarditis. The gene discussed is CD40LG; the disease is myocarditis.