In this study, the change (difference from baseline) in Lp-PLA2 activity was associated with changes in plasma n-6 PUFAs, including LA, DGLA and AA; however, a multiple regression analysis revealed that only the change in LA was independently and positively correlated with the change in Lp-PLA2 activity—a hallmark of inflammation, atherosclerosis and CVD [2, 12]. Here, PLA2G7 is linked to atherosclerosis.