TP53 and urothelial carcinoma: Gene deletion and mutation are frequently involved in the development of human urothelial carcinoma, such as the deletion in chromosome 9 (Schulz, 2006; Knowles, 2008), point mutations of the fibroblast growth factor receptor-3 (FGFR3) (Iyer and Milowsky, 2013; Pandith et al., 2013), and alterations in tumor suppressor gene TP53 and RB1 (Mitra et al., 2006) and FHIT (Baffa et al., 2000).